Indian Journal of Clinical and Experimental Ophthalmology

Lens protein glycation in diabetic and senile cataract patients

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Article Type : Research Article

Author Details: Prachi Shukla,Manisha Arora*,Roshan Kumar Mahat,Sudeep Kumar,,Sumesh Prasad Sah

Volume : 5

Issue : 3

Online ISSN : 2395-1451

Print ISSN : 2395-1443

Article First Page : 395

Article End Page : 397


Introduction: Cataract is an abnormality in lens, characterized by decreased transparency and increased cloudiness and may progress to severe visual impairment if left untreated. Glycation of lens protein crystallins is considered as the major mechanism for the formation of cataract. The study was undertaken with the aim to estimate glycated protein in lens of diabetic cataract patients and to compare it with senile cataracts.
Materials and Methods: A total of 60 lenses were collected. Of which, 30 were from diabetic cataract subjects and rest 30 were from subjects of senile cataract. Glycated protein was measured in the lenses of all participants.
Results: The level of lens glycated protein was found to be significantly increased in subjects of type 2 diabetes mellitus compared to senile cataract patients.
Conclusion: In conclusion, the results of the present study indicate that glycation of lens protein may play an important role in the development of cataract with greater extent in diabetic patients compared to senile group.

Keywords: Cataract, Crystallins, Diabetes mellitus, Glycation.

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