IP Indian Journal of Immunology and Respiratory Medicine

Burden of smoking on the pulmonary diffusing capacity in asymptomatic smokers with chronic kidney disease in comparison to non-smokers with chronic kidney disease

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Article Type : Research Article

Author Details: Prasanna Purna K,K Kalyani*,M Manoj Kumar,K Sai Sindhu,K Venkata Manohar

Volume : 4

Issue : 3

Online ISSN : 2581-4222

Print ISSN : 2581-4214

Article First Page : 150

Article End Page : 153


Background: The study was aimed to assess the additional risk of smoking as a risk factor on lung function and gaseous exchange by measuring diffusion capacity of lung for carbon monoxide (DLCO or TLCO) in chronic kidney disease patients (CKD) on hemodialysis.
Methodology: This was a cross-sectional observational study among smokers and non-smokers with chronic kidney disease who were clinically stable in the last four weeks, without a past history of pulmonary and cardiac disorders. Spirometry and DLCO tests were performed within 24 hours after hemodialysis.
Results: There were 40 CKD subjects on hemodialysis included in the study and were categorized into two groups as smokers & non-smokers. Smokers which included current smokers and forever smokers. All were males with the median age of 49.47 years and mean body mass index of 22.85 ± 2.29 kg/m2 and with a mean hemoglobin level of 9.59 ± 1.58 g/dl among Non-smokers and 8.63 ± 1.51 g/dl among smokers. The mean of DLCO among non-smokers with CKD was 49.35% of LLN of the normal value of DLCO which is mild to moderate degree of reduction and 25.48% among smokers with CKD which is of a severe degree of reduction. There was a significant relation between DLCO reduction with smoking history and also with CKD with a p-value of <0>
Conclusion: Reduction of diffusion capacity of the lung is common in chronic kidney disease patients even though not symptomatic. Risk factors for DLCO reduction like smoking further increase the disease burden adding to further morbidity with more decrease in DLCO.

Keywords: Carbon monoxide diffusing capacity; Chronic kidney disease; Smokers; Non-smokers.

Doi :-https://doi.org/10.18231/j.ijirm.2019.034