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Year 2019

Volume: 5 , Issue: 2

Print ISSN:-2581-4753

Online ISSN:-2581-4761

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IP International Journal of Medical Microbiology and Tropical Diseases


Association of Candida and its antifungal susceptibility pattern in patients with pulmonary tuberculosis


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Author Details: Kavitha Y, Khaja Moinuddin, Anandi V., Hajaabdul Nazeer

Volume : 3

Issue : 3

Online ISSN : 2581-4761

Print ISSN : 2581-4753

Article First Page : 126

Article End Page : 128


Abstract

Aim: The purpose of this study was to determine the incidence of Candida species and antifungal susceptibility pattern among smear positive pulmonary tuberculosis patients in a coastal tertiary care teaching hospital.
Materials and Method: One hundred and twenty one sputum samples were found to be positive for acid fast bacilli by Ziehl-Neelsen stain. All positive sputum samples were taken into consideration and subjected to standard mycological procedures.
Results: Out of 121 patients sputum samples positive for acid fast bacilli, Candida co infection was revealed in 41 samples(33.89%). Candida albicans was the most common species isolated and accounted for 60.98% followed by C.tropicalis(21.95%), C.krusei(9.76%) and C.glabrata(7.31%). Out of 539 AFB negative sputum samples, 107(19.85%) samples yielded the growth of Candida. Candida albicans 69 (64.49%) was the most commonest species followed by Candida tropicalis 35(32.71%). Majority of C.albicans and C.tropicalis were showed resistance to azole group. Only 52% of susceptibility exhibited towards fluconazole and clotrimazole by Candida albicans. Susceptibility of C.tropicalis towards fluconazole(55%) and clotrimazole(33%) was also high. All strains of C.krusie and C.glabrata were showed susceptibility to azole group as well as amphotericin B. Few strains of C.albicans(12%) and C.tropical(12%) were shown resistance to amphotericin B.
Conclusion: Candida co infection was found in 33.8% of 121 AFB proven pulmonary tubedrculosis patients. Antifungal susceptibility testing revealed resistance  to tested azole drugs as well as to amphtericin B. Hence there is a need to perform the Antifungal susceptibility testing before administering antifungals.

Keywords:
Candida albicans, CHROM agar, Tuberculosis.