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Indian Journal of Microbiology Research


In vitro study of meropenem and colistin combination against multidrug resistant clinical isolates from patients with burns


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Author Details : Jaswinder Singh Gill, Ketoki Kapila

Volume : 3, Issue : 4, Year : 2016

Article Page : 401-404


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Abstract

Background: Nosocomial infections are known in patients treated at tertiary care hospitals. However this acquires significance as some of these are resistant to most of the major categories of antibiotics. Treatment of such infections become more challenging while treating patients in burn wards. There is a pressing requirement to evaluate combinations of some of the available antibiotics to treat these nosocomial infections in burns patients. No study evaluating combination of meropenem and colistin on clinical isolates of burns patients in a tertiary care hospital is available.
Objective: To evaluate synergistic effect of meropenem and colistin antibiotic combination on common multidrug resistant bacteria isolated from the burn ward patients.
Methods: A total of 46 strains of multidrug resistant bacteria which included 23 strains each of P. aeruginosa and Acinetobacter baumannii were tested forin-vitro synergistic effect of meropenem and colistin combination. MIC and FIC index was calculated for all the bacterial isolates.
Result: 18 out of 23 strains of P. aeruginosa and 19 out of 23 strains of Acinetobacter baumannii showed synergistic activity.
Conclusion: This study suggests that the combination of meropenem and colistin could be a good alternative for the treatment of Acinetobacter and Pseudomonas infections in burns patients, until a newer antibiotic agent is available.

Keywords:
Combination antibiotics, Chequer board titration, Fractional Inhibitory Concentration Indices (FICI), Meropenem-colistin combination, Multidrug-resistance

How to cite : Gill J S, Kapila K, In vitro study of meropenem and colistin combination against multidrug resistant clinical isolates from patients with burns. Indian J Microbiol Res 2016;3(4):401-404

Copyright © 2016 by author(s) and Indian J Microbiol Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)