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Indian Journal of Microbiology Research


Evaluation of risk factors and bacteriological profile of Neonatal Sepsis among patients admitted at Navodaya Medical College, Hospital and Research Center, Raichur


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Author Details: Sneha S. Hegadi, Ashish Jitendranath

Volume : 4

Issue : 3

Online ISSN : 2394-5478

Print ISSN : 2394-546X

Article First Page : 298

Article End Page : 304


Abstract

Introduction: Neonatal sepsis accounts for 69% of neonatal deaths in the developing world. Bacterial isolates and their antibiotic susceptibility has constantly been changing, which depends on several factors like gestational age, birth weight, maternal risk factors, place of delivery, mode of delivery.
Materials and Method: Blood samples from 200 clinically suspected neonatal septicemia cases were subjected to aerobic culture. Detailed history including risk factors and clinical findings were recorded. The culture isolates obtained were tested for antibiotic susceptibility pattern.
Results: Of the 200 cases studied, 92[46%} were blood culture positive which included 49[53.26%] males, 62[67.39%] were preterm and 53[57.60%] were very low birth weight, 68[73.91%] were spontaneous vaginal delivery and 59 [64.13%] were hospital out born neonates. Early onset septicemia was more common, seen in 66.33% of cases than late onset septicemia in 33.69% cases. Gram positive organisms were predominant in 59.78% of cases than Gram negative organisms in 42.39%. Majority of Gram negative isolates were susceptible to Ertapenem, Cefepime followed by Aztreonam and Gram positive isolates were 100% susceptible to Vancomycin, Linezolid and 100% resistance to Penicillin, Tetracycline.
Conclusion: In a setting with high fatality rates, high risk of mortality in neonatal sepsis has to be identified and targeted for intensive intervention.

Keywords:
Neonatal septicemia, Blood culture, Susceptibility pattern, Risk factors