Volume : 4
Issue : 3
Online ISSN : 2394-5478
Print ISSN : 2394-546X
Article First Page : 316
Article End Page : 319
Multidrug resistant organisms (MDROs) infections have increased in recent years. The antibiotic resistance development in clinical isolates of Enterobacteriacae is rapid and that spread in the hospital.
Objectives: 1)To detect multidrug resistant Enterobacteriacae 2)To determine frequency of MDR Enterobacteriacae isolates by site of infection. 3)To determine antibiotic susceptibility pattern of multidrug resistant Enterobacteriacae.
Materials and Method: Antibiotic susceptibilities of bacterial isolates from clinical specimens were determined according to standard guidelines. MDRO detection was based on the joint definition given by the European Center for Disease Prevention and Control (ECDC) and the Centers for Disease Prevention and Control (CDC).(6)
Results: Out of 1585 clinical samples, 961(61%) samples had enterobacteriacae isolates. Out of total 961 Enterobacteriacae species studied, 648 (41 %) species were MDR. The commonest MDR Enterobacteriacae species were E. coli 364/519 (54%), followed by Klebsiella sp. 280/431 (45%). The commonest MDR Enterobacteriacae infections were urinary tract infections 400/648 (61%), followed by respiratory infections 133/648 (21%). MDR Enterobacteriacae isolates showed decreased sensitivity towards third generation cephalosporins, aminoglycosides and fluroquinolones.
Conclusion: The early detection of MDR bacterial species should be started by all microbiology laboratories to give effective treatment to the patients and to reduce the cross infections to other patients in hospital as well as to reduce threat of antimicrobial resistance which is at present a global problem.
Keywords: Enterobacteriacae, Multidrug resistant organisms (MDROs)