IP Indian Journal of Neurosciences


Nerve conduction study findings of subclinical diabetic neuropathy in newly diagnosed diabetic patients


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Author Details: Ram Babu Singh, Kuldeep Chandel, Sudhir Kumar

Volume : 1

Issue : 1

Online ISSN : 2581-916X

Print ISSN : 2581-8236

Article First Page : 1

Article End Page : 7


Abstract

Background: Diabetes induced neuropathy is one of the most challenging complication of diabetes mellitus and is one of the major causes of non-traumatic limb amputation. The exact  prevalence of diabetic neuropathy is not known and reports shows variable prevalence. There are good number of patients, who have subclinical neuropathy at the time of detection of diabetes.
Aim: He aim of this study was to investigate the prevalence of subclinical neuropathy in newly diagnosed diabetic patients.
Methods and Material: In this study, 104 diabetic patients and 50 healthy subjects have been studied prospectively during 2011 - 2012, in OPD of Department of Medicine, M.L.B. Medical college, Jhansi. All patients were clinically asymptomatic. At least one abnormal independent neurophysiological nerve parameters, which were required as the criterion of the peripheral  nervous system sub clinical involvement, following results were drown.
Results: The mean MNCV was significantly lower in the diabetic group (39.0 ± 5.0 m/s) when compared with non-diabetic controls (53 ± 4 m/s; P=0.0001). The mean SNCV value of case (44.05+/-11.8 m/s) and control (46+/-5 m/s) had no significant difference( p value=.37). In motor nerve conduction studies, the distal motor latency (DML) is most frequent abnormal parameter in studied nerves of upper limbs, while mean f, and MNCV is the most frequent abnormality in lower limb nerves. In all sensory nerve conduction study, the most  frequent abnormal parameter was the onset of latency.
Conclusion: We conclude that the percentage of abnormal electrophysiological parameter in different motor and sensory nerve were 77% in sural nerve, 66% in peroneal nerve, 63.4% in posterior tibial nerve, 57% in median motor nerve, 46.6% in ulnar motor nerve, 40% in median sensory nerve, and 47% in ulnar sensory nerve. Thus, the incidence of subclinical neuropathy is significantly higher in newly detected diabetics in this study.

Key word:
Nerve Conduction, Subclinical Diabetic Neuropathy