Indian Journal of Obstetrics and Gynecology Research

Prospective comparative study for analysing efficacy of L-Arginine against all essential aminoacids infusions in patients of oligohydramnios

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Author Details: Nitin N. Kulkarni, Harshil P. Shah, Laxmikanth R. Kanade

Volume : 4

Issue : 1

Online ISSN : 2394-2754

Print ISSN : 2394-2746

Article First Page : 54

Article End Page : 58


Background: Oligohydramnios (reduced amniotic fluid) found to be responsible for many complications like Mal-presentations, Umbilical cord compression, Meconium aspiration syndrome and hence increased operative delivery. Maintenance of maternal hydration, supplementation of antioxidants and essential amino-acids is mainstay of treatment. Various modalities are available to treat oligohydramnios & reducing complications of oligohydramnios.
Objective: To compare efficacy of L- Arginine sachets versus All Essential Amino-Acids(EAA) infusions for treatment of oligohydramnios cases.
Study Design: Prospective comparative study.
Materials and Methods: A total of 100 women attending antenatal clinic diagnosed with oligohydramnios were included in our study. 50 patients received only L-Arginine sachets(5 gm twice a day). Another 50 received all EAA infusion(200 ml on alternate day preceded by 500 ml of 10% fructodex). Results of both the groups were obtained in view of -Mean increase in liquor, intervention delivery interval, and neonatal outcome.
Results: The Mean Gestational age at the time of recruitment was 32.3 and 31.6 weeks in study and control group respectively. The mean AFI at the time of enrollment was 6.13 ±0.53, 6.10 ±0.31 in both groups respectively. Patients were delivered at ≥ 37 weeks (in study group 80% in control group 78%). The Mean AFI at the end of therapeutic intervention was (8.63 ± 0.71 and 8.53 ± 0.70, in study group and control group respectively), so we got improvement in mean AFI by 2.50 ± 0.18 in study group and 2.43 ± 0.39 in control group. There was no significant neonatal morbidity in these patients. Significant improvement in liquor volume was obtained in both the groups.
Conclusion: Treatment with L-Arginine and All EAA infusion resulted in significant improvement in liquor and prolongation of duration of pregnancy. But L-Arginine sachets are more cost effective and without hospitalization. Also there is no significant difference between results of study and control groups.

Keywords: Oligohydramnios, L-Arginine sachets, All Essential amino-acids infusions