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Indian Journal of Obstetrics and Gynecology Research

Role of tranexamic acid in reducing maternal mortality and need of surgical intervention in women with clinically diagnosed postpartum hemorrhage

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Author Details: Rashmi Naganagoudaru, Vinaya Goudar

Volume : 4

Issue : 4

Online ISSN : 2394-2754

Print ISSN : 2394-2746

Article First Page : 373

Article End Page : 375


Postpartum hemorrhage accounts for > 25% of deaths, an effective treatment for postpartum hemorrhage (PPH) would contribute importantly to the Millennium Development Goal of decreasing maternal mortality.
Objective: To observe whether the antifibrinolytic agent, tranexamic acid reduces maternal mortality, need of hysterectomy in women with diagnosed postpartum hemorrhage and to evaluate adverse drug reaction of tranexamic acid.
Materials and Method: This study was conducted at Department of OBG, Karnataka Institute of Medical Sciences(KIMS) Hubli during May 2010 to April 2011. Hundreds women who has been diagnosed PPH were included in the study. Patients were allocated into two groups:
Control group (fifty case) and Study group (fifty case). To collect and quantify amount of collected blood, BRASS-V˶ drape was used. Numbers and cause of maternal mortality was evaluated. Surgical intervention or hysterectomy required for failed medical management, and maternal side effects caused by tranexamic acid were noted.
Results: Both groups are comparable with regards to, age, parity distribution, type of delivery, causes of PPH (p-value> 0.05). Mean blood loss in control group was 744±102ml while that in tranexamic acid group was 626±113ml this difference between the two groups was highly significant (p value<0.0001). Hence in terms of blood loss tranexamic acid group is more efficacious when compared to control group. There was no maternal mortality due to failure of treatment of post partum hemorrhage in both the groups. None of patients needed surgical intervention or hysterectomy for failed medical treatment of PPH. In two groups side effect like thrombosis is not seen either in control group or tranexamic acid group.
Conclusion: Tranexamic acid significantly reduced the blood loss and maternal morbidity and mortality in patients with post partum haemorrhage.

Keywords: Hysterectomy, Maternal mortality, BRASS-V˶ drape, Tranexamic acid, Blood loss