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Indian Journal of Obstetrics and Gynecology Research


EFFECT OF LIVER DISEASE ON MATERNAL AND FETAL OUTCOME –EXPERIENCE IN A TERTIARY HOSPITAL


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Author Details: Reema Sircar, Geetanjali Pawar

Volume : 2

Issue : 2

Online ISSN : 2394-2754

Print ISSN : 2394-2746

Article First Page : 65

Article End Page : 68



Abstract

Objective: To determine the frequency, causes and outcome of liver disease in pregnant women. Setting: Tertiary care teaching hospital.
Method(s): All pregnant women with liver disease attending the inpatient or outpatient services of the Department of Obstetrics and Gynecology over a period of 3 years were evaluated and followed up till delivery or death.
Results: The study included 40 patients of Cholestatic jaundice, 38 patients of viral hepatitis, 15 patients of sepsis, 5 patients of HELLP syndrome and 1 patient each of hyperemesis gravidarum, amoebic abscess, enteric hepatitis & acute cholecystitis with pancreatitis. Intra hepatic cholestasis of pregnancy was the most common and least detrimental cause of liver disease in pregnancy. Number of preterm deliveries and incidence of LSCS was highest with HELLP Syndrome. ICU admissions were maximum with diagnosis of Hepatitis E and NICU admissions highest with HELLP Syndrome. Both HELLP Syndrome and Hepatitis E were responsible for maximum maternal and perinatal deaths. Conclusions: Liver disease in a pregnant woman needs to be treated with caution.

Key words: Liver Disease, Cholestatic Jaundice, Viral Hepatitis, HELLP Syndrome, Perinatal Outcome