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Indian Journal of Obstetrics and Gynecology Research

Study of genital tuberculosis and its impact on fertility in a tertiary care centre

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Author Details: Prashanta Krishna Gupta,Sangeeta Rai*

Volume : 5

Issue : 4

Online ISSN : 2394-2754

Print ISSN : 2394-2746

Article First Page : 544

Article End Page : 548


Objective: To assess ovarian reserve in infertile women with genital tuberculosis and compare with women with proven fertility by hormonal and ultrasound markers of ovarian reserve.
Materials and Methods: A cross-sectional study was conducted at an outpatient S S Hospital BHU, Varanasi, India with 50 women with Gestational Tuberculosis (GTB) and 50 healthy controls. Ovarian reserve tests were done by estimating serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), on day 3 of a natural menstrual cycle and anti-Mullerian hormone (AMH) in any day of cycle. On D3 Antral Follicles Count (AFC) were also estimated on Ultrasound.
Result: The median FSH was 8.91 (5.60-11.07) mIU/ml, LH 6 (4.65-8.55) mIU/ml and the mean E2 61.30±15.23 pg/ml which were significantly higher than controls (FSH-5.50, LH-3.80, and E2-41.53). The median AMH levels 1.23 ng/ml was significantly lower in GTB than controls (AMH-2.50). And, the median AFC 6.0(4.0-8.0) was significantly lower in GTB than control 11.0 (8.25-12.0).
Conclusion: The median FSH, LH and the mean E2 on day-3 of cycle and AMH on any day of cycle along with AFC are good predictors of Ovarian reserve and found to be low in GTB.

Keywords: Tuberculosis, Infertility, Ovarian reserve, Anti mullerian hormone.

Doi :-https://doi.org/10.18231/2394-2754.2018.0122