Indian Journal of Obstetrics and Gynecology Research

Assessment of endothelial dysfunction by brachial artery flow mediated dilation in postmenopausal women at low risk for cardiovascular disease

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Article Type : Research Article

Author Details: Sandeep Sharma*,Pratibha Gupta,Piyushi Sharad

Volume : 6

Issue : 3

Online ISSN : 2394-2754

Print ISSN : 2394-2746

Article First Page : 377

Article End Page : 381


Introduction: The increase in life expectancy has resulted in increased population of menopausal women
hence menopausal health has become a priority in Indian scenario. World Health Organization defines
menopause as permanent cessation of menstruation due to the loss of ovarian follicular function or
surgical removal of ovaries. The abrupt disruption of estrogen is a risk factor for cardiovascular diseases
among postmenopausal women. Endothelial dysfunction is an important predictor for determining early
atherosclerotic risks.
Aims and Objectives: This study aimed to compare endothelial dysfunction measured by brachial artery
flow mediated dilation (BAFMD) in non obese, non-diabetic post menopausal women with their agematched
menstruating controls.
Materials and Methods: This is a cross-sectional study of 100 women in the age group of 45-55 years
attending gynaecology clinic in the department of Obstetrics and Gynaecology in PGIMER Chandigarh a
tertiary centre of north India. Parameters recorded were height, weight, BMI, Blood pressure. Biochemical
parameters studied were Fasting blood sugar, Post-prandial blood sugar, Lipid profile. Measurement of
Brachial artery flow mediated dilation (BAFMD) was done in all patients. Framingham risk score (FRS)
was also calculated in all.
Results: T he mean age in both case and control was 49.40 3.6 48 years. Mean BAFMD was 8.334
2.47(%) in postmenopausal women whereas It was 7.335 3.01(%) in premenopaus al women. The
difference was not found to be significant.
Conclusion: The correlation of duration of menopause with FMD made us conclude that endothelial
dysfunction increases as the duration of menopause increases.

Keywords: Edothelial dysfunction, Brachial artery flow mediated dilation, Menopausal women, Estrogen, Framingham risk score.

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