Indian Journal of Obstetrics and Gynecology Research


Autologous platelets rich plasma a potential therapeutic modality for cervical regeneration in erosions and cervicitis prospective observational study in a teaching hospital of central India


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Article Type : Research Article

Author Details: Sapna Jain,Vivek Khare*,Rashmi Tripathi

Volume : 6

Issue : 3

Online ISSN : 2394-2754

Print ISSN : 2394-2746

Article First Page : 382

Article End Page : 387


Abstract

Introduction: Biological reagent like PRP having strong anti–inflammatory and healing effect due to
large number of growth factors and paracrine action thus plays a crucial role in cell protection, repairing
and regeneration of epithelial tissues, curing deep seated inflammation thus protecting patient from long
term consequences of chronic inflammation. Adult women worldover are commonly affected by cervicitis,
Symptoms of it can be similar to vaginitis with persistent vaginal discharge, itching, heaviness and
dysperiunea. It can be ca used by sexually transmitted infection as well as due to trauma, frequent douching
and chemical irritants. This chronic in flammation of the cervix has a high recurrence rate due to its complex
pathophysiology and leads to long term consequences like pelvic inflammatory disease, infertility, ectopic
pregnancy, chronic pelvic pain, increased predisposition to HPV & HIV infection and even it can be a
precursor of cervical cancer.
Aim: To compare post treatment symptom relief and healing of damaged cervix in patient undergoing
either conventional or PRP therapy for chronic cervicitis and erosions.
Materials and Methods: This study was a single center, prospective observational study conducted at L N
Medical college and research centre Bhopal M.P. A total of 120 patients with CC having similar symptoms
were enrolled and out of which 60 randomly selected patients were given conventional treatment and
remaining 6 0 were undergone PRP therapy. PRP was prepared from patients own blood in our institutional
lab and injected immediately in the targeted areas of cervix at 3- 4 sites and result compared.
Result: Better Clinical benefits and healed epithelium were observed o n follow up visits in the PRP treated
patient as compared to conventional treatment in addition increased perception of recovery in patients
within the prp group compared with the conventional group. No complications were reported in both
therapy.
Conclusion: We have shown that PRP is a biological, safe effective and viable option for the cure of
cervicitis as well as protecting patient from its significant consequences due to better regeneration and
healing of cervical epithelium without any additional medication.

Keywords: Chronicervicitis, Autologous, PRP Plattelts poor plasma, Growth factors, Infertility, Cancer cervix.

Doi :-https://doi.org/10.18231/j.ijogr.2019.083