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IP International Journal of Ocular Oncology and Oculoplasty

Clinicopathological study of ocular surface squamous neoplasia in non-HIV patients and effect of topical cyclosporine

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Author Details: Dadapeer K, Sahana R. Manipur, Kavitha CV, Pavana Acharya, Lakshmi BR

Volume : 3

Issue : 1

Online ISSN : 2581-5016

Print ISSN : 2581-5024

Article First Page : 54

Article End Page : 56


Introduction: Ocular Surface Squamous Neoplasia is a spectrum of conjunctival and corneal epithelial neoplasia manifesting as dysplasia, carcinoma-in-situ and squamous cell carcinoma. Study was aimed to know the clinicopathological manifestations of OSSN in non-HIV patients and efficacy of topical cyclosporine.
Methods: 4 patients with conjunctival growth on medial side of eye suspecting OSSN were studied and all 4 underwent wide surgical excision followed by histopathological investigation. Followed up with topical 0.05% cyclosporine drops twice a day for 8 weeks.
Results: Case 1 and 2 showed moderately differentiated Squamous cell carcinoma. Case 3 showed full thickness dysplasia and case 4 showed conjunctival tissues with no evidence of malignancy. Case1 showed recurrence after 2 months and case 2 and 3 did not show recurrence.
Conclusion: OSSN in Non-HIV patients can present in similar fashion to HIV patients but with better prognosis.

Dysplasia, Non-HIV patients, Ocular surface squamous neoplasia, Squamous cell carcinoma, Topical Cyclosporine