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International Journal of Pharmaceutical Chemistry and Analysis


Similarity Analysis studies on (Sulfonyl) Benzene Derivatives as Anti HIV Agents


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Author Details : Shweta Sharma, Smrita Singh, Mymoona Akhter, Sarvesh Paliwal

Volume : 3, Issue : 3, Year : 2016

Article Page : 174-182


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Abstract

Introduction: The present investigation was undertaken to understand the overlaying problems of mutation in HIV virus leading to failure to combat AIDS.
Materials and Methods: In present study Multiple Linear Regression (MLR) analysis was carried on a series of 71(sulfonyl) benzene analogs reported as viral nucleocapsid protein zinc finger modulators for HIV.
Results: The MLR model obtained using carbo method (N*N) similarity showing good predictive ability, r2 (training) = 0.655, r2(test) = 0.605.
Conclusion: The results indicated that Refractivity Similarity (polarizability and volume) and Shape Similarity are important parameters in predicting the activity of viral nucleocapsid protein zinc finger inhibitors.

Keywords:
Refractivity Similarity, Shape Simliarity, Carbo, MLR, Viral Nucleocapsid Protein Zinc Finger, HIV

How to cite : Sharma S, Singh S, Akhter M, Paliwal S, Similarity Analysis studies on (Sulfonyl) Benzene Derivatives as Anti HIV Agents. Int J Pharm Chem Anal 2016;3(3):174-182

Copyright © 2016 by author(s) and Int J Pharm Chem Anal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)