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International Journal of Pharmaceutical Chemistry and Analysis


Similarity Analysis studies on (Sulfonyl) Benzene Derivatives as Anti HIV Agents


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Author Details: Shweta Sharma, Smrita Singh, Mymoona Akhter, Sarvesh Paliwal

Volume : 3

Issue : 3

Online ISSN : 2394-2797

Print ISSN : 2394-2789

Article First Page : 174

Article End Page : 182


Abstract

Introduction: The present investigation was undertaken to understand the overlaying problems of mutation in HIV virus leading to failure to combat AIDS.
Materials and Methods: In present study Multiple Linear Regression (MLR) analysis was carried on a series of 71(sulfonyl) benzene analogs reported as viral nucleocapsid protein zinc finger modulators for HIV.
Results: The MLR model obtained using carbo method (N*N) similarity showing good predictive ability, r2 (training) = 0.655, r2(test) = 0.605.
Conclusion: The results indicated that Refractivity Similarity (polarizability and volume) and Shape Similarity are important parameters in predicting the activity of viral nucleocapsid protein zinc finger inhibitors.

Keywords:
Refractivity Similarity, Shape Simliarity, Carbo, MLR, Viral Nucleocapsid Protein Zinc Finger, HIV