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International Journal of Pharmaceutical Chemistry and Analysis


A validated UV-Visible Spectrophotometric method for Levosulpiride in bulk and Pharmaceutical formulation


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Author Details : Prasanth SS, Akhila V, Snijarukku PG, Fathimath Suhana T

Volume : 3, Issue : 4, Year : 2016

Article Page : 235-239


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Abstract

The Levosulpiride in bulk and Pharmaceutical formulation was estimated by a validated UV-Visible spectrophotometer method. The λ max obtained for Levosulpiride was 288.1nm in 0.1 N HCl. The drug shows linearity in a concentration range of 6-36µg/ml. The correlation coefficient for standard graph was found to be 0.999. The assay percentage of marketed formulation by the proposed method was good with label claim. The accuracy of the method was checked by recovery experiment performed at three different levels 80%, 100%, 120% and the percentage recovery was in the range 98.00-102.00%. The % RSD found was low which in turn is an indication of the accuracy and reproducibility of the method.  Precision study of the method carried out as intra-day, inter-day variations and repeatability which was in good agreement with %RSD. The proposed method was found to be rugged and robust. Hence the above method can be applied for routine analysis of Levosulpiride in bulk and in pharmaceutical dosage form.

Keywords:
Area under Curve, Levosulpiride, Validation

How to cite : Prasanth Ss, Akhila V, Snijarukku Pg, Fathimath Suhana T, A validated UV-Visible Spectrophotometric method for Levosulpiride in bulk and Pharmaceutical formulation. Int J Pharm Chem Anal 2016;3(4):235-239

Copyright © 2016 by author(s) and Int J Pharm Chem Anal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)