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International Journal of Pharmaceutical Chemistry and Analysis


Effectiveness of N-[3-Chloro-2-(Substituted)-4-Oxazetidin-1-Yl]-4-(1h-Indol-3-Yl) Butanamide Derivatives as Α-Amylase Inhibitors


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Author Details : Neethu Mathew1, *, M. Sukumar2, T. K Ravi3, Arunkumar R4, Betty Carla5

Volume : 2, Issue : 1, Year : 2015

Article Page : 38-41


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Abstract

 Various N-[3-Chloro-2-(substituted)-4-oxazetidin-1-yl]-4-(1H-indol-3-yl) butanamide derivatives have been synthesized by the cyclo condensation of Schiff bases with tri ethyl amine and chloro acetyl chloride. The structures of the newly synthesized compounds have been established on the basis of their spectral data. All compounds were evaluated for α-amylase inhibitory activity. All compounds investigated exhibited significant activity, comparable to that of the standard used.

 

Keywords: N-[3-Chloro-2-(4-hydroxy-3-methoxy phenyl)-4-oxazetidin-1-yl]-4-(1H-indol-3-yl) butanamide, α-amylase inhibitor.

 

How to cite : Mathew1 N, *, Sukumar2 M, Ravi3 T K, Arunkumar R4, Carla5 B, Effectiveness of N-[3-Chloro-2-(Substituted)-4-Oxazetidin-1-Yl]-4-(1h-Indol-3-Yl) Butanamide Derivatives as Α-Amylase Inhibitors. Int J Pharm Chem Anal 2015;2(1):38-41

Copyright © 2015 by author(s) and Int J Pharm Chem Anal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)