International Journal of Pharmaceutical Chemistry and Analysis

Comparative study of olanzapine and risperidone in the control of positive and negative symptoms in the treatment of schizophrenia

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Author Details: Supriya Sharma, Yeshwant Deshmukh, Priya Ann Sam, Urmila Salve

Volume : 5

Issue : 1

Online ISSN : 2394-2797

Print ISSN : 2394-2789

Article First Page : 7

Article End Page : 11


Objective: To compare the efficacy of olanzapine and risperidone in the treatment of positive and negative symptoms of schizophrenia.
Materials and Methods: The study was conducted in MGM medical college Navi Mumbai between October 2012 to September 2014. The study included 110 patients of schizophrenia. The positive and negative symptoms were assessed with the help of the PANSS (positive & negative symptom score) scale.
Results: We observed that the mean percentage reduction in score in the positive scale of PANSS was 48.74% in the risperidone and 49.40% in the olanzapine group .The negative score reduced by 56.32% in the Risperidone group and by 61.59% in the olanzapine group on the PANSS.
Conclusion: olanzapine was superior to risperidone in controlling the positive as well as negative symptoms of schizophrenia clinically but the results were not statistically significant.

Keywords: Olanzaine, Risperidone, Schizophrenia.


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