International Journal of Pharmaceutical Chemistry and Analysis


Synthesis of novel pyridine containing azetidinone derivatives as a potential anti tubercular activity


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Author Details: N. Pramod, B. Mayuri

Volume : 5

Issue : 1

Online ISSN : 2394-2797

Print ISSN : 2394-2789

Article First Page : 39

Article End Page : 42


Abstract

Six novel pyridine containing azetidinones Azt 1-6 have been synthesized from Schiff base by treating Pyridine-4-carbaldehyde with Substituted aromatic amines each were taken equimolar concentration in presence of Glacial acetic acid as a catalyst using Grindstone technique. Further Schiff base add benzene, triethylamine and chloro acetyl chloride undergoes condensation followed by elimination reaction result into novel pyridine containing azetidinone derivatives. The newly synthesized derivatives were characterized by using spectroscopic methods (IR, 1H-NMR, MASS) and screened for selected anti-tubercular. In vitro anti-tubercular activity was performed using Micro plate Alamar Blue Assay (MABA) method. Among synthesized compounds Azt5 and azt6 showed more potent Anti TB activity than standards.

Keywords: Pyridine-4-carbaldehyde, Schiff base, Azetidinones, anti-tubercular activity.

Doi :-https://doi.org/10.18231/2394-2797.2018.0007