International Journal of Pharmaceutical Chemistry and Analysis


Substituted benzimidazoles: A novel class of anti-tubercular agents


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Article Type : Research Article

Author Details: Senthilraja Manivannan*

Volume : 6

Issue : 1

Online ISSN : 2394-2797

Print ISSN : 2394-2789

Article First Page : 10

Article End Page : 13


Abstract

Reaction of O-phenylenediamine with phthalic anhydride gives 2H-benzimidazole -1-yl-3, 8 - benzpyrolidine - 2-one (I) This on condensation with anthranilic acid and 4-aminoacetophenone gives II. II on reaction with different aldehydes in presence of sodium hydroxide and ethanol stirred at room temperature for 24 h gives N-[4-(3-Aryl-acryloyl)–phenyl]–2-(1H– benzimidazol–2–yl)–benzamide (III-X). All the compounds have been characterized by elemental analysis, IR and NMR and Mass spectral analysis. All the compounds have been evaluated for their anti-tubercular activity against different stain of mycobacterium species.

Keywords: Benzimidazole, O-phenylenediamine, Tuberculastatics, Antimicrobials, Aminobenzaldehyde.

Doi :-https://doi.org/10.18231/j.ijpca.2019.003