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International Journal of Pharmaceutical Chemistry and Analysis

Synthesis of some nuclear substitution derivatives of 4-acetyl pyridine

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Author Details: Joohee Pradhan, Anju Goyal

Volume : 2

Issue : 3

Online ISSN : 2394-2797

Print ISSN : 2394-2789

Article First Page : 113

Article End Page : 119


Five nuclear substitution derivatives of 4- acetyl pyridine (2a to 6a) were prepared via N-oxidation followed by either nitration or arylation in the yield of 60-80%. Substitution at 2- position is promoted due to the electron withdrawing and meta- directing ability of acetyl group at 4- position making the pyridine N-oxide vulnerable to attack at C-2.

4- acetyl pyridine, N-oxidation, nitration, arylation, nuclear substitution.