Volume : 2
Issue : 2
Online ISSN : 2457-0087
Print ISSN :
Article First Page : 37
Article End Page : 42
Aim: The main objective of this case-control study is to determine the effect of initial periodontal treatment of scaling and root planing on oxidative stress biomarkers in smokers and non-smokers with chronic periodontitis (CP).
Materials and Method: The study included 114 patients with CP (57 smokers and 57 non-smokers). Serum and saliva samples were collected and clinical periodontal measurements were recorded at baseline, first and third months after periodontal therapy. 8-hydroxydeoxyguanosine (OHdG) and enzyme activity of glutathione peroxidase (GSH-Px) were analyzed with enzyme-linked immunosorbent assay.
Results: The level of 8-OHdG, and GSH-Px was found to be significantly higher in saliva and serum of both periodontitis groups. Levels of these ROS were significantly higher in smokers than in non-smokers groups. After initial periodontal treatment, levels of 8-OHdG in serum and saliva were significantly decreased in both periodontitis groups.
Conclusion: Initial periodontal therapy with Scaling and Root planing will be helpful in diminishing oxidative stress in periodontitis.
Keywords: Periodontitis, Smoking, Reactive oxygen species, 8 hydroxydeoxyguanosine, Glutathione reductase.