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Indian Journal of Pathology and Oncology

Spectrum of lesions in non-neoplastic nephrectomy specimens and their clinico-pathological correlation- a tertiary care hospital experience

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Research Article

Author Details : Sushma Praveen Kulkarni*, Dayanand Sonkawade, Namrata Patro, Sahiba Kaur, Manoj Sawadkar

Volume : 6, Issue : 4, Year : 2019

Article Page : 574-578

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Introduction: Nephrectomy is a common surgical procedure done in neoplastic as well as many
non-neoplastic conditions affecting kidney. Poor renal functioning is a major burden contributing to
Materials and Methods: This is a prospective and retrospective study conducted to study the
clinicopathological correlation of non-neoplastic nephrectomy specimen. The significant gross and
microscopic findings were tabulated for studying the relative frequency of different non neoplastic
conditions affecting the kidney.
Result: In our study we found that 70 to 85 % of total nephrectomies were for non-neoplastic indications.
Hydronephrosis was by far the commonest indication for nephrectomy. The peak age ranges were 31-
40 yrs and 51-60 yrs for males and 31-40 yrs for females. Both males and females showed right sided
nephrectomy more common than left sided.
On microscopy, the predominant finding was glomerular sclerosis in 38% of the specimens and
hyalinization of the glomeruli in 23% of the cases. Chronic inflammation was by far the commonest finding
with lymphocytes, plasma cells infiltrating the interstitium in all the studied specimens. It was observed
that chronic pyelonephritis with end stage kidney disease and hydronephrosis were by far the commonest
diagnosis offered contributing to 88% of the cases.
Conclusion: Our study concludes that chronic pyelonephritis, hydronephrosis are the commonest nonneoplastic
conditions contributing to the nephrectomy burden. As these are a treatable group of conditions,
they should be well identified in the earlier stages so that many such nephrectomies can be avoided.

Keywords: Nephrectomy, Pathology, Microscopy, Non-neoplastic.

Doi : 10.18231/j.ijpo.2019.112

How to cite : Kulkarni S P, Sonkawade D, Patro N, Kaur S, Sawadkar M, Spectrum of lesions in non-neoplastic nephrectomy specimens and their clinico-pathological correlation- a tertiary care hospital experience. Indian J Pathol Oncol 2019;6(4):574-578

Copyright © 2019 by author(s) and Indian J Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (