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Indian Journal of Pathology and Oncology


Diversity and diagnostic challenges in salivary neoplasms


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Research Article

Author Details : Jenita Christiana Samson, Umamaheswari Karuppanan*, Indumathi Balakrishnan, Narmatha Murugesan

Volume : 6, Issue : 4, Year : 2019

Article Page : 597-602


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Abstract

Introduction: Salivary gland lesions exhibit a wide spectrum of clinical and morphological diversity. The
aim of this study was to evaluate the relative frequencies, types, site, distribution and histomorphological
features of salivary gland lesions.
Materials and Methods: A retrospective study for a period of two years was done on 40 cases of salivary
gland lesions in the department of pathology at KAPV medical college, Trichy a Tertiary care centre. Cases
were analysed based on demographics, anatomical locations and histopathological types. Specimens were
fixed in 10% formalin, processed and embedded in paraffin. Sections were stained by hematoxylin and
eosin. Histopathological examination was done by microscopy. Special immunohistochemical stains were
used for certain rare cases of interest.
Results: Out of 40 cases, 35 cases (87.5%) were neoplastic and 5 cases (12.5%) were non neoplastic.
The mean age of presentation was 38.925 (13-67yrs) with equal gender distribution. Regarding the site
distribution, Parotid was the common site for location of salivary tumours (18 cases, 45%). Most common
benign tumour was pleomorphic adenoma (22 cases, 78.5%) followed by basal cell adenoma (4 cases,
14.2%). Among malignant tumours, mucoepidermoid carcinoma ranks the first (4 cases, 57.1%). One case
of Acinic cell carcinoma, adenoid cystic carcinoma with dedifferentiation, and a rare recently described
variant mammary analogue secretory carcinoma were also observed.
Conclusion: Histopathology remains the gold standard for diagnosing salivary gland lesions. They have
broad morphological spectrum and overlaps between tumour types. Immunohistochemistry serves as an
adjunct tool to support histopathological diagnosis. It helps in planning treatment protocols to reduce
morbidity and mortality.

Keywords: Salivary neoplasms, Dedifferentiated adenoid cystic carcinoma, Mammary analogue secretory carcinoma.

Doi : 10.18231/j.ijpo.2019.116

How to cite : Samson J C, Karuppanan U, Balakrishnan I, Murugesan N, Diversity and diagnostic challenges in salivary neoplasms. Indian J Pathol Oncol 2019;6(4):597-602

Copyright © 2019 by author(s) and Indian J Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)