Indian Journal of Pathology and Oncology


A study on the histomorphological correlation of renal tumors using Fuhrman grading and TNM Staging


Full Text PDF Share on Facebook Share on Twitter


Author Details: K. Suresh, K. Florence Nightingale, V. Vydehi, K. Shilpa

Volume : 4

Issue : 4

Online ISSN : 2394-6792

Print ISSN : 2394-6784

Article First Page : 489

Article End Page : 494


Abstract

Renal cell carcinomas are aggressive tumors which are stratified based on Fuhrman grading and TNM staging for prognosis. The total number of cases of renal cell carcinomas used for this study was 40. Clinicomorphological variables were correlated. Clear cell carcinoma accounted for maximum number of lesions. The clinical manifestations included hypertension, flank pain; flank mass but all features were noted only 10 cases. All the cases showed a male preponderance and common age group was 4th to 6th decade. Furhman Grade and TNM stage can be used as single independent prognostic factors. Clear cell and papillary renal cell carcinomas were low grade tumors with PT1-3 and Furhman grade I or II. Sarcomatoid and undifferentiated carcinomas were high grade tumors with PT4 and furhman grade IV. There was no positive correlation between necrosis of the tumor and Furhman grade, most patients had Furhman grade I or II. There was no correlation between histologic subtype and necrosis. Size alone is not an independent predictive prognostic factor. Microvessel involvement and peripelviceal sinus involvement was seen in sarcomatoid variant. None of the cases in this study showed adrenal involvement.

Keywords: Reanl cell carcinoma, Furhman Grade, TNM stage, Immunohistochemistry