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Indian Journal of Pathology and Oncology


Association of Ki67 expression with clinicopathological parameters and molecular classification in invasive breast carcinomas


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Article Type : Research Article

Author Details: Anuradha Patil,Sushma Nigudgi*,Shabnam Karangadan,S. K. Andola

Volume : 6

Issue : 2

Online ISSN : 2394-6792

Print ISSN : 2394-6784

Article First Page : 207

Article End Page : 212


Abstract

Breast carcinoma is most common malignant tumour and leading cause of cancer death in women worldwide. Ki67 has a prediction of prognosis in breast carcinoma patients, and is also considered has an important biomarker in routine practice.
Aim: The aim of the present study was to investigate Association of Ki67 expression with clinicopathological parameters and molecular classification in invasive breast carcinomas.
Materials and Methods: A total of 100 patients diagnosed as invasive breast cancer were included in the present study. The clinical information of the patients was obtained from the institutional medical records. The expression levels of Ki67 were detected by immunohistochemical analysis. The associations between Ki67 scores and other clinicopathological parameters were evaluated.
Results: The value of the Ki67 scores in all the patients was, low in 57 cases (57%), intermediate in 11 cases (11%), high in 32 cases (32%) with a mean score of 33.33%. Ki67 expression was significantly associated with middle aged women, ranging from 31-50yrs (P<0>
Conclusion: In conclusion, results revealed that there is presence of significant correlations between Ki67 and other clinicopathological parameters and molecular classification of breast cancer. Thus, Ki67 labeling index is an important prognostic and predictive member in management of breast carcinoma patients.

Keywords: Invasive breast carcinoma, Ki67 Labeling Index, Clinicopathological parameters, Molecular subtypes.

Doi :-https://doi.org/10.18231/j.ijpo.2019.040