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Indian Journal of Pathology and Oncology


Role of Prothrombin time International normalized ratio and activated partial thromboplastin time in beta thalassemia major: A cross sectional study


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Article Type : Research Article

Author Details: Karthik Srevatsa*,Ranjit P Kangle,Sujata M Jali

Volume : 6

Issue : 2

Online ISSN : 2394-6792

Print ISSN : 2394-6784

Article First Page : 237

Article End Page : 241


Abstract

Objectives: To evaluate the changes in PT/ INR and APTT in Beta thalassemia major cases.
Materials and Methods: A cross sectional study was conducted on 100 patients diagnosed with beta thalassemia major.
Results: Mean PT was noted to be 15.58s and mean APTT was 41.05s. These were elevated than controls and statistically significant. Association between serum ferritin and INR was not statistically significant. Correlation graph analysis between age and APTT was positive and significant while that for ferritin and APTT was negative.
Conclusion: Significant alterations in PT / INR and APTT exist in beta thalassemia major patients. Additional parameters and a tailored approach is suggested.

Keywords: PT, APTT, INR beta thalassemia Major.

Doi :-https://doi.org/10.18231/j.ijpo.2019.047