Indian Journal of Pharmacy and Pharmacology


Method Development and Validation for Simultaneous Estimation of Rizatriptan Benzoate and Naproxen Sodium by UV Spectrophotometric Method


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Author Details: Varshini K, Mahaboobunnisa Md, Chandini NB, Apurupa P, Latha PM, Prasanthi T, Lakshmana Rao A

Volume : 3

Issue : 1

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 1

Article End Page : 6


Abstract

A Simple, validated, accurate and precise simultaneous UV Spectrophotometric method has been developed for the simultaneous estimation of Rizatriptan Benzoate (RIZ) and Naproxen Sodium (NAP) in pharmaceutical dosage form. Rizatriptan Benzoate exhibits absorption maximum at 282.9nm and Naproxen Sodium shows absorption maximum at 261.8nm in methanol. The Beer’s law obeyed the concentration range of 5-30µg/ml for RIZ and NAP. Mean recovery of 100.25% for RIZ and 99.2%5 for NAP respectively signifies the accuracy of the method. This method can be used for the routine simultaneous estimation of RIZ and NAP in pharmaceutical dosage forms.

Keywords:
Rizatriptan benzoate, Naproxen sodium, Estimation, Spectrophotometry, Dosage form