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Indian Journal of Pharmacy and Pharmacology


FORMULATION AND EVALUATION OF MATRIX TABLETS OF ROPINIROLE HYDROCHLORIDE FOR ORAL CONTROLLED RELEASE


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Author Details : M. Mohan Varma, and M. Santosh Kumar

Volume : 2, Issue : 1, Year : 2015

Article Page : 27-42


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Abstract

The objective of the present investigation is to prepare and evaluate the controlled release matrix tablets of a water soluble drug (ropinirole hydrochloride) using direct compression and Wet granulation technology. Ropinirole Hydrochloride is a hydrophilic drug and has pH independent solubility. It is used in the treatment of idiopathic parkinsonsdisease. The controlled release matrix tablets of ropinirole hydrochloride were prepared using various polymers: guargum, sodium alginate and carbopol 940P.The matrix tablets were prepared using two strategies: direct compression and wet granulation. The tablets were evaluated for the various quality control parameters and the drug release was evaluated in pH 1.2 and in pH 7.4 buffer. The optimized formulation containing drug and guar gum controlled the drug release up to 8 hours. The drug release from the optimized formulation (drug: guar gum,1:2.5) followed first order kinetics and showed non-fickian diffusion mechanism. The FTIR studies indicated the lack of drug-polymer interaction. The formulated controlled release tablets can decrease the frequency of drug administration, decrease the plasma drug fluctuation and it can improve the patient compliance.

Key words: Ropinirole Hydrochloride, Controlled release, matrix tablets

How to cite : Varma M M, Kumar A M S, FORMULATION AND EVALUATION OF MATRIX TABLETS OF ROPINIROLE HYDROCHLORIDE FOR ORAL CONTROLLED RELEASE. Indian J Pharm Pharmacol 2015;2(1):27-42

Copyright © 2015 by author(s) and Indian J Pharm Pharmacol. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)