Volume : 4
Issue : 1
Online ISSN : 2393-9087
Print ISSN : 2393-9079
Article First Page : 27
Article End Page : 28
Objective: To evaluate the antidepressant activity of Rosuvastatin in male albino mice.
Method: Thirty male swiss albino mice were selected for tail suspension model. There were five groups and each group had six animals. The control group received Normal saline (10ml/kg I.P), the standard Imipramine (10mg/kg I.P), the 3 test group received Rosuvastatin (10mg/kg, 15mg/kg, 20mg/kg I.P) respectively. The test was conducted 30mins after injecting the drugs.
Duration of immobility was noted. Statistical analysis was performed using Mean +/- SEM. One way ANOVA followed by Tukey’s post hoc test was done P<0.05 was considered statistically significant.
Results: Rosuvastatin produced significant antidepressant effect at all the doses, as indicated by reduction in the duration of immobility compared to the control and standard with significant p value of<0.0001.
Conclusion: The results of the present study indicates the antidepressant like activity of Rosuvastatin in male albino mice.
Keywords: Rosuvastatin, Antidepressant, Albino mice