Indian Journal of Pharmacy and Pharmacology


Synthesis and antimicrobial screening of some novel quinazolinones and its derivatives


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Author Details: B. Satya Sree, A. Lakshmana Rao, P. Swathanthra Babu, K. Surya Kiran, K. Vandana

Volume : 4

Issue : 3

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 130

Article End Page : 133


Abstract

Various novel quinazolinones and quinazolidine dione derivatives were prepared by using anthranilic acid. Anthranilic acid was synthesized by treating phthalimide with sodium hypobromide solution. The synthesized anthranilic acid was treated with urea, thiourea, acetamide and benzamide to give corresponding titled compounds in good yields. The synthesized compounds were characterized by physical properties and spectral studies (IR, 1H-NMR) and tested for antimicrobial activity.

Keywords:
Anthranilic acid, Urea, Thiourea, Benzamide, Quinqzolinones and Quinazolidine diones