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Indian Journal of Pharmacy and Pharmacology

Analysis of clinical relevance of chrono pharmacology in therapy of respiratory disorders in a tertiary care hospital- A prospective observational study

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Author Details: Dharani Devangi, Shashirekha C.H, Shruthi S L

Volume : 4

Issue : 4

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 184

Article End Page : 187


Introduction: Drugs following administration itself affect the biological rhythm or biological rhythm can affect the drug action. Administration of drugs according to biological rhythm helps in optimization and quantification of the drug effects and thereby aids in potentiation of desired effects while minimizing the undesired effects.
Objectives: To study the chronopharmacological relevance to time of drug administration in respiratory disorders in Medicine in-patients at a tertiary care hospital.
Methodology: A prospective non- interventional observational study was conducted on Medicine inpatients of a tertiary care hospital to study the relevance of chronopharmacology in respiratory disorders. Patients were included in the study based on inclusion and exclusion criteria. Data was recorded on a predesigned proforma.
Results: Theophylline, montelukast, levocetrizine, chlorpheniramine have been administered appropriately at bedtime and prednisolone accordingly in the morning in all the subjects thereby showing 100% relevance. However etophylline was administered according to chronopharmacology in 71% of subjects only.
Conclusion: Most of the drugs recorded in the study were administered according to their relevance to circadian rhythm, while only a few drugs are lagging in the trend which needs to be addressed.

Keywords: Chrono pharmacology, Circadian rhythm, Respiratory disorders, Theophylline, Etophylline, Montelukast, Levocetrizine, Chlorpheniramine, Prednisolone.