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Indian Journal of Pharmacy and Pharmacology


Assessment and analysis of adverse drug reactions in outpatient department of mental hospital of a tertiary care teaching institute of central India


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Author Details: Vatsala Maheshwari, Pali Rastogi, Pooja Solanki Mishra

Volume : 4

Issue :

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 207

Article End Page : 209


Abstract

Objective: To monitor and analyze the adverse drug reactions (ADRs) in outpatient department of mental hospital of a tertiary care teaching institute of central India. To assess the causality between drug and adverse reaction using WHO-UMC scale.
Method: A total of 209 adverse drug reactions were recorded in ICSR form obtained from CDSCO website in a period of 6 month from December 2016 to May 2017 in outpatient –department of mental hospital. Causality was assessed according to WHO-UMC causality scale.
Result and Conclusion: Among 209 ADRs recorded 2 ADRs were excluded from further analysis because these were belonging to unlikely category of WHO-UMC causality scale. In this analysis 48.32% ADRs were certain, 32.05% ADRs were probable and 18.66% ADRs were possible. In this analysis 57% cases of ADRs were belonging to male while 43% cases were belonging to female .The maximum ADRs were reported in 21-30 years of age group (35.2%) followed by 31-40 years of age group (27%). The antipsychotics were responsible for maximum ADRs (71.02%), antidepressants were causing 12.07% of ADRs, antiepileptic were causing 14.5% of ADRs, ant manic drugs (lithium) were responsible for 2.4% cases of ADRs. CNS is most commonly affected system (44.92%), followed by metabolic side effects (37.68%).Olanzapine was the most common offending drug and weight gain was the commonest adverse drug reaction.

Keywords: Adverse drug reactions (ADRs), Psychotropic drugs, Analysis, CDSCO, Weight gain, Olanzapine.