Indian Journal of Pharmacy and Pharmacology


FORMULATION AND EVALUATION OF FAST DISINTEGRATING TABLET CONTAINING HYDROCHLOROTHIZIDE


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Author Details: Abhishek Soni, Raju L.

Volume : 2

Issue : 2

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 119

Article End Page : 133


Abstract

The aim of this study was to prepare Fast disintegrating tablet containing Hydrochlorothiazide by using Natural disintegrants. The tablets were prepared using micro crystalline cellulose as diluent and aspartame as sweetening agent along with Natural super disintegrant. The superdisintegrant used in this study was Isapghula mucilage and Banana powder. The tablets were evaluated for weight variation, hardness, friability, wetting time, water absorption ratio and disintegration time (DT) and dissolution study. Different concentration of superdisintegrant was used in this formulation as 2%, 4%, 6%, 8%. From the results obtained, it can be concluded that the tablet formulation prepared with 8% with Isapghula mucilage ie. 8 mg showed fast and higher drug release (97.68%) during in vitro dissolution study. Also the hardness, friability, dissolution rate and assay of prepared tablets (batch F8) were found to be acceptable according to standard limits.


Key Word: Fast disintegrating Tablet, Superdisintegrant, Hydrochlorothiazide, Isapghula mucilage, Banana powder.