Indian Journal of Pharmacy and Pharmacology


A study at BRIMS hospital for comparing the tolerability of Cilnidipine and Amlodipine in the treatment of hypertension


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Article Type : Research Article

Author Details: Preeti M Dharpur*,Kavitha V.C

Volume : 6

Issue : 1

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 11

Article End Page : 13


Abstract

Introduction: Few of the antihypertensive medicine have been withdrawn owing ADRs. Some are serious enough leading to hospitalization or withdrawal of treatment.
Objective: To study the tolerability of Cilnidipine and Amlodipine in patients of hypertensive.
Materials and Methods: This study was a collaboration between department of Pharmacology and Medicine of Bidar Institute of Medical Sciences (BRIMS), Bidar. Duration of study was for 9 months from May 2018- January 2019. 100 newly diagnosed mild and moderate hypertensive patients of either sex aged between 18-60yrs were included. ADR were noted and compared using parametric test. Significance was defined as P < 0>
Result: The patients mean age receiving Cilnidipine was 42.98 ± 8.35 and Amlodipine was 44.48 ± 9.03. On comparison of ADRs between Cilnidipine and Amlodipine it is clear that Amlodipine has more ADRs than Cilnidipine. The Comparison of pedal edema between both the groups show a Statistical Significance with p= 0.0003.
Conclusion: It can be concluded from our study that Cilnidipine seems to be better than Amlodipine in the management of the hypertensive patients.

Keywords: ADRs, Cilnidipine, Amlodipine, Antihypertensive drugs.

Doi :-https://doi.org/10.18231/2393-9087.2019.0003