IP Journal of Diagnostic Pathology and Oncology


Correlation of anti-thyroid peroxidase antibody levels with status of thyroid function among the tribal population residing in hilly area


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Author Details: Satish Arakeri, Geetha Vasu

Volume : 1

Issue : 2

Online ISSN : 2581-3706

Print ISSN : 2581-3714

Article First Page : 21

Article End Page : 23


Abstract

Background: Autoimmune thyroid diseases are most frequent thyroid disorders among young females. Among autoimmune thyroid disorders, Hashimoto’s thyroiditis is the most common one. The most reliable confirmatory diagnostic test is estimation of anti-thyroid peroxidase (TPO) levels in blood. The present study deals with estimation of anti-TPO levels in relation to age, gender and thyroid stimulating hormones (TSH) in the tribal region of Wayanad, Kerala, India.
Objective and Methods: In the present study, total 100 cases have been selected where anti-thyroid peroxidase antibodies and thyroid stimulating hormone (TSH) levels have been estimated.
Result: Our present study includes total 100 cases. 57 cases show raised TPO antibodies. Hence 57% cases are considered to be having Hashimoto’s thyroiditis. Most common age group affected by Hashimoto’s thyroiditis is 3rd-4th decade females. Out of 57 cases showing raised TPO antibodies, 27 cases (47%) shows raised TSH values, so considered to be hypothyroid. 21 cases (37%) show normal TSH value, hence are euthyroid. Lastly, 9 cases (16%) show low TSH value, are hyperthyroid.
Conclusion: Hashimoto’s thyroiditis patient can manifest as hypothyroid, euthyroid as well as hyperthyroid, hence only clinical findings with estimation of T3, T4 and TSH doesn’t suffice for diagnosis. Around 20% of cases do present with hyperthyroidism, hence in addition to anti thyroglobulin (for Grave’s disease), one has to test for Anti TPO antibodies level to rule Hashimoto’s thyroiditis with toxic features.

Keywords:
Thyroid peroxidase, Thyroid stimulating hormone, Hashimoto’s, Hypothyroidism