IP Journal of Diagnostic Pathology and Oncology


Analysis of spectrum of Prostate lesions in correlation with Serum Prostate specific antigen levels – A clinicopathological study in a tertiary care centre


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Article Type : Research Article

Author Details: R Sujatha,T Jaishree*,Y A Manjunatha

Volume : 4

Issue : 3

Online ISSN : 2581-3706

Print ISSN : 2581-3714

Article First Page : 175

Article End Page : 179


Abstract

Introduction: Diseases of prostate, particularly Benign prostate hyperplasia and prostate adenocarcinoma
accounts to considerable mortality and morbidity in elderly male. Serum Prostate specific antigen along
with Digital rectal examination and transurethral resection/trucut biopsies of prostate plays a crucial role
as initial line of investigation in diagnosis of prostate pathology.
Objectives: This study is undertaken with the aim to analyze various clinico – histopathological parameters
of prostate lesions and its correlation with serum Prostate specific antigen.
Materials and Methods: This is a prospective study conducted in Histopathology section of Department
of Pathology, Dr. B R Ambedkar medical College and Hospital, Bangalore during June 2017 to June 2019.
Results: A total of 134 cases of prostate specimens were analyzed. Most common lesion to be encountered
was Benign Prostate hyperplasia followed by Prostate adenocarcinoma. Most of the benign lesions were
found in sixth decade and malignant lesions in seventh decade. Increased frequency of micturition is
the most common presenting symptom. Among Prostate adenocarcinoma, the Gleason pattern 4 and the
Gleason score 7 is the most commonly encountered. Serum Prostate specific antigen showed correlation
with both benign and malignant lesions.
Conclusion: In the current scenario, histopathological analysis of prostate specimens plays crucial role in
both diagnosis and management along with other aids such as serum PSA levels and imaging modalities.

Keywords: Adenocarcinoma, Benign prostate hyperplasia, Serum prostate specific antigen.

Doi :-https://doi.org/10.18231/j.jdpo.2019.037