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Journal of Pharmaceutical and Biological Sciences


Phytochemical screening, in-vitro antioxidant and cardioprotective potential of monochoria vaginalis on doxorubicin induced cardiotoxicity


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Author Details : R. Varadharajan, S. Palani

Volume : 5, Issue : 2, Year : 2017

Article Page : 56-66


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Abstract

The present investigations were undertaken to identify photochemical present in the ethanolic leaf extract of Monochoria vaginalis by GC MS/MS, evaluation of the in vitro antioxidant and cardioprotective activity against DOX-induced cardiotoxicity in rats. The invitro antioxidant potential like DPPH radical scavenging activity, Reducing Power, Superoxide anion Scavenging activity and Nitric oxide Radical Scavenging Activity was assessed. The extent of heart damage and effect of the plant extract was assessed by various biochemical parameters like xanthine oxidase phospho lipase, phospho lipid, glycogen and lipid peroxidase were determined. In the monochoria vaginalis extract 16 compounds were identified by GC–MS/MS. Ethanolic extract of Monochoria vaginalis exhibit strong antioxidant activity. The pretreatment with monochoria vaginalis at two doses (250 mg/ kg and 500 mg /kg) to DOX treated rats significantly prevented the altered enzymes phospholipase, xanthine oxidase and lipid peroxides were enhanced following depletion of glycogen and phospholipids .This study showed that the antioxidant and cardioprotective potential of monochoria vaginalis, therefore scientifically embankment the use of this plant in traditional medicine for treatment of heart diseases.

Keywords: Cardioprotection, Monochoria vaginalis, Doxorubicin, xanthine oxidase, phospholipase, Antioxidant

How to cite : Varadharajan R, Palani S, Phytochemical screening, in-vitro antioxidant and cardioprotective potential of monochoria vaginalis on doxorubicin induced cardiotoxicity. J Pharm Biol Sci 2017;5(2):56-66

Copyright © 2017 by author(s) and J Pharm Biol Sci. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (creativecommons.org)