Journal of Pharmaceutical and Biological Sciences


Impact of rifaximin potency after treatment with different solvents


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Author Details: Ana Carolina Kogawa, Hérida Regina Nunes Salgado

Volume : 5

Issue : 3

Online ISSN : 2320-1924

Print ISSN :

Article First Page : 77

Article End Page : 80


Abstract

Rifaximin is an oral antibiotic used for the treatment of hepatic encephalopathy, ulcerative colitis, irritable bowel syndrome, Clostridium difficile, travelers' diarrhea and acute diarrhea. Production of rifaximin involves the use of different solvents. The performance of these solvents can affect the activity of this antimicrobial. The general objective of this work is to show the importance in the rigorous production of rifaximin raw material. The specific objectives of this work are to show that the use of different solvents or even a modification in the process of obtaining the raw material can lead to different activities of powder. A purposeful change in the process of obtaining the rifaximin raw material by recrystallization, using different solvents, resulted in significant changes in antimicrobial activity. This is an alert to the production of pharmaceutical inputs. The process of obtaining raw material must be standardized, aiming not only the quality of the medicine, but also, aiming the consequences of the use of non-quality medicines that generate a vicious cycle in the public health system.

Keywords: rifaximin, antibiotic, raw material, antimicrobial activity, quality