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Journal of Pharmaceutical and Biological Sciences

Cinnamic acid and lanostenoic acid derivatives from the leaves of Pyracantha crenulata (D. Don) M. Roem

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Author Details: Shahnaz Sultana, Mohammed Ali, Showkat Rasool Mir

Volume : 5

Issue : 3

Online ISSN : 2320-1924

Print ISSN :

Article First Page : 91

Article End Page : 95


Pyracantha crenulata (D. Don) M. Roem. (Rosaceae) is distributed in the northern Himalayas and China as a perennial shrub. The leaves are used to prepare herbal teas, sun burn creams and facial creams and taken as a nervine tonic. An air-dried leaf powder of P. crenulata was exhaustively extracted with methanol. The concentrated leaf extract was adsorbed on silica gel (60-120 mesh) for the preparation of a slurry. The dried slurry was chromatographed over silica gel column packed in petroleum ether. The column was eluted with petroleum ether, chloroform and methanol successively in order of increasing polarity to isolate β-sitosterol, cis-3,4-dioxyethylene-5-methoxycinnamic acid and lanost-54-en-2β,3β-diol 26-oic acid (cranulanostenoic acid). The structures of all the isolated phytoconstituents have been established on the basis of spectral data analysis and chemical reactions.

Keywords: Pyracantha crenulata, leaves, chemical constituents, isolation, characterization