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Journal of Pharmaceutical and Biological Sciences


Mangiferin a bioactive compound of mangifera indica l on oxidative damage and antioxidant status in n-diethylnitrosoamine induced hepatocellular carcinoma in animal model


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Author Details: R Maheswari*,M Saranya

Volume : 6

Issue : 4

Online ISSN : 2320-1924

Print ISSN :

Article First Page : 114

Article End Page : 124


Abstract

Our study aims at elucidating the antioxidant efficiency of Mangiferin from (Mangifera indica L.) for its protective effect beside N-Nitrosodiethylamine induced Hepatocellular carcinoma (HCC) in rat liver carcinogenesis. Studies have shown that N-Nitrosodiethylamine induces lipid peroxidation and alters the antioxidant status in non-target organisms. An effort has been made to study the effect of N-Nitrosodiethylamine induced Hepatocellular carcinoma on biochemical parameters and ameliorating results of Mangiferin. Animals were segregated to six groups. Group A served as control, Group B induced with 0.01% DEN through water for 15 weeks to induce hepatocellular carcinoma. Group C received Mangiferin via intragastric intubation at a daily dose of 30 mg/kg body weight for 16 weeks every day. Groups D to F animals received 0.01% of DEN as in Group B along with Mangiferin via intragastric intubation at a daily dose of 10, 20 and 30 mg/kg body weight for throughout the experimental period for 4 month. The study highlights the effectiveness of Mangiferin as protective molecule against N-Nitrosodiethylamine induced carcinoma. Histological studies of liver tissue too correlated with the above biochemical findings. These results clearly suggest that Mangiferin treatment prevents liver damage, lipid peroxidation and protects the antioxidant defense system in DEN-induced liver carcinogenesis in rats.

Keywords: Mangifera indica L, Mangiferin, N-Nitrosodiethylamine, Antioxidants, Antioxidant enzymes.

Doi No:-10.18231/2320-1924.2018.0016