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Indian Journal of Clinical Anatomy and Physiology

Effect of isometric handgrip test on heart rate variability in primary open angle glaucoma

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Author Details: Arijita Banerjee, Indu Khurana

Volume : 4

Issue : 1

Online ISSN : 2394-2126

Print ISSN : 2394-2118

Article First Page : 4

Article End Page : 7


Introduction: Open angle glaucoma is a chronic, slowly progressive optic neuropathy characterised by progressive visual field loss. At systemic level; hypertension, hypotension leading to reduced ocular blood flow (OBF), vasospasm, oxidative stress and cardiovascular disease history are associated with glaucoma. Various studies suggest a relation between Open angle glaucoma (OAG) and autonomic dysfunction, yet the exact mechanism is still unclear. Heart rate variability (HRV) and a provocative cardiac stress test can provide an easy, non-invasive and indirect assessment of the autonomic control of the heart.
Material and Method: The present study consists of 20 patients with Primary Open angle Glaucoma (group ІІ) and 20 age & sex matched healthy controls (group І). Frequency domain analysis of HRV at rest and during Handgrip testing was analysed.
Results: On immediate release of handgrip patients with POAG depicted a significant raised Low frequency variables LF (nu) (73.39± 4.04), (p < 0.000) and LF/HF ratio (2.79±0.17), (p < 0.000). On the other hand there is a step decrease in high frequency variable HF (nu) (32.04±1.83) in group ІІ (p = 0.002).The decrease in HF (nu) (38.40±8.07), (p < 0.000) with high LF/HF (1.55±0.28), (p<0.000) in group ІІ remained significant during recovery period. 
Conclusion: The study thus concluded sympathetic overdrive in response to stress and low parasympathetic activity during recovery period suggestive of impaired autonomic activity in Primary Open angle Glaucoma.

Stress Test, Autonomic Dysfunction, Primary Open Angle Glaucoma, Auto Regulation, Heart Rate Variability

Doi No:-10.18231