International Journal of Clinical Biochemistry and Research


Serum ferritin level in type 2 diabetes mellitus - A case control study


Full Text PDF



Author Details: Sangappa Virupaxappa Kashinakunti, Kavitha Hiremath, Manjula Rangappa, Gurupadappa Shantappa Kallaga

Volume : 3

Issue : 1

Online ISSN : 2394-6377

Print ISSN : 2394-6369

Article First Page : 62

Article End Page : 66


Abstract

Background: Hyperferritinemia probably contributes insulin resistance and subsequently to decreased insulin secretion causes for development of insulin resistance.
Objectives: Compare HbA1c with Ferritin and find correlation between HbA1c and ferritin in type 2 diabetes mellitus patients, and also to find the best cut-off value for serum ferritin.
Material and methods: The study was conducted on type 2 diabetes mellitus patients attended the outpatient department. Totally 99 participants were enrolled for the study, out of which 49 were cases and 50 were age and sex controls.  The FBS, PPBS, HbA1c and serum ferritin were estimated. Statistical package for social science software version 19.0 was used for statistical analysis.
Results: There statistically significant increase in all the biochemical parameters viz FBS, PPBS, HbA1c and serum ferritin levels in cases compared controls. The p value was 0.0001 for all the parameters, which is highly significant. There was a positive correlation between the HbA1c and Ferritin levels, but it was not statistically significant (r = 0.10). The area under the ROC curve for serum ferritin values at various cut-off was 0.904 and the best cut-off of serum ferritin levels greater than 124ng/ml.
Conclusion: Serum ferritin levels were higher in type 2 Diabetes mellitus which positively correlated HbA1c. Thus, routine screening for serum ferritin concentration in diabetes patients can be done to assess the glecemic control in type 2 DM.

Key words:
Type 2 Diabetes Mellitus, Serum ferritin

Doi No:-10.18231