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Indian Journal of Clinical and Experimental Ophthalmology

The intraocular pressure changes following intravitreal bevacizumab injections in an Indian population

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Author Details: Yogish S. Kamath, Ashish Rander, Shailaja B S, Lavanya G. Rao, Sulatha V Bhandary

Volume : 4

Issue : 1

Online ISSN : 2395-1451

Print ISSN : 2395-1443

Article First Page : 85

Article End Page : 88


Aim:  To assess the changes in Intraocular pressure (IOP) after intravitreal bevacizumab therapy.
Design: Prospective, Observational, Tertiary care hospital based study.
Participants: 95 patients receiving intravitreal bevacizumab, for varying indications, were included.
Materials and Methods: A study of the change in intraocular pressure of 95 patient eyes receiving intravitreal injection of bevacizumab for varying indications was performed at 4hours, 2 weeks and 6 weeks post injection.
Results: There was a statistically significant increase in IOP 4 hours post injection [p value= .000; 95% confidence limits of -2.07 to -1.11; mean difference of -1.59]. There was no statistical significance in IOP rise at 2 weeks (p= 0.32; 95 % confidence limits of -1.13 and 0.18; mean difference of -0.47) or at 6 weeks (p= 1.00; 95% confidence limits of -0.86 to 0.44; mean difference of -0.21). The endpoint IOP in the single injection and multiple injection groups was statistically insignificant (t=-0.32, df = 92, significance value=0.749, 95% confidence interval -1.48 to 1.07).
Conclusion: Although a statistically significant short-term rise in IOP was observed, this increase was clinically insignificant. The IOP reverted towards baseline values on subsequent visits at 2 weeks and 6 weeks post-injection. The number of injections did not have any effect on the IOP change.
Clinical significance: Our study evaluated the effect of intravitreal injection of bevacizumab on intraocular pressure in an Indian population and found no clinically significant rise in the same.

Keywords: Bevacizumab, Intraocular pressure, VEGF-A.

Doi No:-10.18231/2395-1451.2018.0020