Indian Journal of Obstetrics and Gynecology Research


Successful controlled ovarian stimulation and pregnancy in a woman with hypogonadotropic hypogonadism resulting from transsphenoidal excision of a pituitary macroadenoma


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Author Details: Salve Archana R, Alka Vijay

Volume : 4

Issue : 2

Online ISSN : 2394-2754

Print ISSN : 2394-2746

Article First Page : 212

Article End Page : 213


Abstract

Introduction: To report pregnancy in women with partial hypopituitarism as a result of surgery for a non-functioning pituitary macroadenoma using recombinant Follicle Stimulation Hormone (rFSH) and Recombinant Luteinizing Hormone (rLH).
Case Description: A 29-year-old woman with partial hypopituitarism underwent Controlled Ovarian Hyperstimulation (COH) with rFSH, rLH achieving a pregnancy. Co-treatment with rLH enhanced FSH action, promoted follicle development and shortened COH duration and reduced FSH doses.
Conclusion: Ovulation induction in women with partial hypopituitarism requires both Follicle Stimulation Hormone (FSH) and Luteinizing Hormone (LH) to achieve optimal follicular growth. Adding LH from start of stimulation optimizes controlled ovarian stimulation in hypogonadotropic hypogonadism supporting the concept that LH is required in the early follicular phase as well.

Keywords:
Controlled Ovarian Hyperstimulation (COH); Luteinizing hormone; IVF/ET; Partial hypopituitarism

Doi No:-10.18231