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Indian Journal of Pathology and Oncology

Histopathological spectrum of cholecystectomy specimens in a tertiary care hospital in Bangalore

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Author Details: Anushree C. N., Sunita B. Patil, Sampath Kumar C., Shwetha Pallavi M. S., H. T. Jayaprakash

Volume : 5

Issue : 1

Online ISSN : 2394-6792

Print ISSN : 2394-6784

Article First Page : 145

Article End Page : 149


Introduction: Gallstone disease is a major health problem and puts notable burden on individuals and health care system worldwide. This research was carried out to study the varied histopathological changes in the gallbladder mucosa as a result of cholelithiasis.
Materials and Methods: The present research comprised 190 gallbladder specimens obtained from cholecystectomy procedures conducted at tertiary teaching hospital in Bangalore. The gross examination was done after fixing the specimens with 10% formalin. Haematoxylin and eosin was used to stain gallbladder sections from fundus, body and neck.
Results: On gross examination, congestion was noticed on surface of gall bladder in 67 cases (35.26%), wall was thickened in more than half of cases 104 (54.74%). Nearly a quarter of specimens showed pathological changes in mucosa of gallbladder (23.15%). Histopathological examination observed evident epithelial hyperplasia in 80 cases (42.1%), antral metaplasia in 20 (10.5%), intestinal metaplasia in 12 (6.3%), dysplasia with carcinoma in one case (0.53%).
Conclusion: Gallstones produce a wide range of histopathological changes in mucosa and calls for dedicated attention of pathologist routinely.

Keywords: Cholelithiasis, Dysplasia, Hyperplasia, Metaplasia.

Doi No:-10.18231/2394-6792.2018.0025