Indian Journal of Pharmacy and Pharmacology


Attenuation of Sub Acute Inflammation by Ethanol Extract of Clerodendrum viscosum Linn. Leaves in Wistar Albino Rats


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Author Details: Sheeba Damodar KP, Chandrashekar R, Mohandas Rai

Volume : 4

Issue : 1

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 8

Article End Page : 10


Abstract

Inflammation is a pathological response of vascular tissue for harmful stimuli caused by injury, infection, environmental agents, malignancy and cellular changes. In our study we have tried to evaluate attenuation effect of Ethanolic extract of Clerodendrum viscosum leaves in Wistar albino rats. Ten Wistar albino rats were randomly assigned to 5 groups. Group 1 served as Controls which received 1 % gum acacia, 3ml/kg, Group 2 received standard drug Indomethacin, 10mg/kg and Group 3, 4 & 5 received the test drug at the dose of 75, 150 & 300 mg/kg. All the drugs were given orally. Rats were anesthetized with pentobarbitone (30mg/kg, intraperitonially) and sterilized cotton pellet was implanted subcutaneously. All animals received drugs once a day for 7 day and on 8th day rats were sacrificed by using high dose of Thiopentone sodium. The average weight of the cotton pellets (dry & wet) and transudative weight were recorded and compared between the groups. Ethanolic extract of Clerodendrum viscosum leaves showed significant sub acute anti-inflammatory activity at the dose of 150mg/kg and 300mg/kg by cotton pellet induced granuloma pouch in Wistar albino rats when compared to controls.

Keywords:
Clerodendrum viscosum Linn. Ethanolic extract, Attenuation, Sub Acute Inflammation

Doi No:-10.18231