Indian Journal of Pharmacy and Pharmacology


“EFFECT OF PRE-OPERATIVE GABAPENTIN ON EARLY POST OPERATIVE PAIN, NAUSEA, VOMITING AND ANALGESIC CONSUMPTION FOLLOWING HYSTERECTOMY IN A TERTIARY CARE TEACHING HOSPITAL: A RANDOMIZED CONTROLLED TRIAL”


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Author Details: Debasis Ray, Samiksha Bhattacharjee

Volume : 2

Issue : 2

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 113

Article End Page : 118


Abstract

Introduction: Gabapentin is not normally used for post-operative pain relief. Presently available data suggest that pre-operative Gabapentin may play role in the management of post operative pain but more work is necessary before recommending it for routine clinical use. So present study was taken up with the objective to evaluate the effects of pre operative Gabapentin on postoperative pain, nausea, vomiting and analgesic consumption.

Methods: A double blind, parallel group, placebo controlled randomized control trial was conducted among 60 patients (30 each in each group) undergoing abdominal hysterectomy to see the effect of 2 hour pre operative administration of single dose of Gabapentin (300 mg) on post operative pain and analgesic consumption. Severity of pain, nausea, vomiting and total analgesic consumption was compared between the two study groups at 4, 24 and 48 after operation.
Results: Statistically significant less median pain score in VAS were seen in Gabapentin group than in placebo group subjects at all time points. Post operatively at 4 hrs and 24 hrs the total dose of analgesic consumption were statistically lower in Gabapentin group (p<0.5) than placebo group. There was no statistically significant difference of nausea and vomiting at 4, 24 and 48 hours post operatively between Gabapentin and placebo group subjects. No patient in any group reported any adverse effects.
Conclusions: This study suggests that pre-operative gabapentin has clinical potential in management of early post operative pain. Low dose Gabapentin (300 mg) can be used as a preemptive analgesic before abdominal Hysterectomy.

Keywords: Gabapentin, Post-operative pain, VAS, Hysterectomy.

Doi No:-10.18231