Indian Journal of Pharmacy and Pharmacology


Method Development and Validation for the Estimation of Saroglitazar in Bulk and Pharmaceutical Dosage Form by RP-HPLC


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Author Details: Hanumantha Rao K, Lakshmana Rao A, Chandra Sekhar KB

Volume : 2

Issue : 3

Online ISSN : 2393-9087

Print ISSN : 2393-9079

Article First Page : 150

Article End Page : 154


Abstract

A simple, rapid, precise and accurate RP-HPLC method was developed and validated for the determination of Saroglitazar in tablet dosage form. Separation of the drug was achieved on a Kromasil C18 Column (150 mm x 4.6 mm I.D., 5 µm particle size). The method showed a linear response in the concentration range of 10-60 μg/ml using 0.1% orthophosphoric acid buffer: acetonitrile as the mobile phase in the ratio of 45:55 v/v with detection at 295 nm with a flow rate of 1 ml/min and retention time was 3.430 min. The method was validated as per the ICH guidelines. The method was successfully applied for routine quality control analysis of Saroglitazar in tablet dosage form.

Keywords
: Saroglitazar, estimation, UV detection, dosage form.

Doi No:-10.18231