Sujatha: Study of dysfunctional uterine bleeding in patients in a medical college hospital


Introduction

Dysfunctional uterine bleeding is defined as excessive heavy (>80ml per month) or prolonged uterine bleeding in the absence of systemic or genital tract pathology. It affects 10% of women and is the most common cause of iron deficiency anemia and gynaecological referrals. Although upto 30% of women report symptoms, this is confirmed on objective measurement in less than a third of cases.

Dysfunctional uterine bleeding is divided in to ovulatory and anovulatory, which is more common in the postmenarchal and perimenopausal age groups. It has been shown that 55.7% of adolescents experience abnormal menstrual bleeding in the first year or so after the onset of menarche because of the immaturity of the hypothalamo-pituitary-ovarian axis leading to anovulatory cycles. It generally takes 18 months to 2 years for regular cycles to be established.

In the premenopausal women who develop menorrhagia due to anovulation, endometrial malignancy should be ruled out prior to deciding the type of treatment. In DUB, hormonal imbalance is considered the root cause of hyperplasia of endometrium that causes menorrhagia due to unopposed influence of estrogen on the endometrium. In some cases, abnormal endometrial haemostasis is the cause of abnormal excessive bleeding.

Metropathia haemorrhagica is a specialised form of DUB. The most common complaint is of continuous vaginal bleeding which may last for many weeks. Bleeding is always painless since it is anovulatory. It is seen in women between 40 and 45 years. It is not related to parity.

There is a mild degree of myohyperplasia, thick polypoidal endometrium. The endometrium shows characteristics of cystic glandular hyperplasia. The swiss cheese pattern is another name given to describe this endometrium. The second feature is the absence of secretory endometrium with the absence of cork-screw glands.

Objectives

To study the prevalence of dysfunctional uterine bleeding in various age groups, correlation of DUB with parity, the incidence of various bleeding patterns and the endometrial profile in dysfunctional uterine bleeding.

Materials and Methods

A retrospective and prospective study was conducted from January 2016 to December 2018 involving 240 patients between 20 – 60 years with symptoms of dysfunctional uterine bleeding presenting to Annapoorana Medical College and Hospital Salem. A total of 255 clinically diagnosed cases of DUB were analysed. Out of these 5 cases were excluded because sample of endometrial biopsy were inadequate. Another 10 cases had organic pathology revealed in biopsy. Thus a total of 240 cases were included in the study.

Inclusion criteria

  1. All women attending OG department without any coagulopathies, tumors, malignancy

  2. Women aged between 20-60 yrs.

Exclusion criteria

  1. Patients with coagulation disorders and hypothyroidism.

  2. Patients with local cervical lesions.

  3. Patients with organic lesions like endometrial polyp, leiomyoma, adenomyosis, incomplete abortion.

Detailed history of the patient was taken. A thorough clinical examination which includes per speculum and per vaginal examination, was done in each case. All patients underwent routine blood investigations and cervical pap smear. Ultrasound of abdomen and pelvis was done in all cases to rule out any organic pathology. A slightly bulky uterus, small ovarian cysts and first degree uterine prolapse were all included in our study. Endometrial samples were obtained by pipelles curette [endometrial aspiration] or by dilatation and curettage. In some cases endometrial histopathology was got from specimens of uterus after hysterectomy.

Endometrial biopsy... using a small, thin catheter (pipelle device) endometrial sampling can be done as OPD procedure. There is no need for any anaesthesia. It was done in patients who were not willing for admission. It is cost effective compared to D&C. Time of endometrial biopsy was premenstrual and sometimes in the bleeding phase. The endometrial sample got was put in 10% formalin and sent for histopathology. Medical management was individualised, as per her age and presentation.

Informed written consent for the study was got from the patients. Tabulations were made with respect to incidence in various age groups, prevalence with respect to parity, the type of bleeding, the type of endometrial histopathology.

Two main types of endometrium are proliferative and secretory. During proliferative stage the stroma becomes extremely edematous, glands become sinous, arteries are coiled. During the secretory phase the most characteristic signs of this phase are found in the glands.

Their epithelial cells develop spherical translucent areas between the nuclei and the basement membrane which contain the precursors of glandular secretion. This characteristic appearance is called subnuclear vacuolation and is presumptive evidence of progesterone activity and therefore of ovulation.

Data were analysed using statistical package for social studies (SPSS) version 18.

Table 1
Parity No of women Percentage
Nulliparity 2 00.83%
Parity1 50 20.83%
Parity2 108 45.00%
Parity3 80 33.33%
Total 240 100.00%

Distribution of cases according to parity

Table 1 shows that DUB is more common in multiparous women, which is congruent with other studies. In a study done at Kathmandu Tribhuvan University teaching hospital in 2014, DUB was found to be more common in parous ladies. The incidence of DUB in women of parity 2 and above was found to be 78.33% in Annapoorana medical college, in the study done at Tribhuvan university teaching hospital Kathmandu it was found to be 88%.

Table 2
Age group No: of cases Percentage
21-30 yrs 12 5.00 %
31-40 yrs 72 30.00%
41-50 yrs 146 60.83%
51-60 yrs 10 4.17%
Total 240 100%

Distribution of patients according to age group

Table 2 the most common age group in which DUB is seen is 41-50 years. Our observations are in consonance with the findings in other studies. In a study done in Thrissur Government medical college, published in 2017, DUB was more common in 41-50 yrs age group (60.83%), followed by the age group 31-40 years(30.00%).

Table 3
Annapoorna medical college salem Nepal medical college kathmandu Thrissur govt medical college Tribhuvan university teaching hospital kathmandu
41-50yrs 41-50yrs 41-50yrs 40-49yrs
60.83% 49.00% 47.6% 63.00%

Most common age group in which DUB is seen, comparison between various colleges

Table 3 shows the comparison between various colleges regarding the highest incidence of DUB. In all these studies DUB was most prevalent in the age groups...41-50 years.

Table 4
Type of bleeding No of cases Percentage
Menorrhagia 118 49.18%
Polymenorrhagia 55 22.92%
Polymenorrhoea 40 16.66%
Metrorrhagia 16 06.66%
Postmenopausal bleeding 11 04.58%
total 240 100%

Distribution of various bleeding patterns

Table 4 the prominent bleeding pattern seen is menorrhagia 49%. This was seen Madhu patil et al,1 Seena KB, Ajithkumar VR,2 Katuwal N et al3 and other studies.

Table 5
Annapoorana medical college salem Nepal medical college kathmandu Azeezia medical college kollam Tribhuvan university teaching hospital nepal
Menorrhagia Irregular bleeding Menorrhagia Menorrhagia
49.18% 46.00% 44.00% 41.60%

Predominant bleeding pattern at presentation comparison between various colleges.

Table 5 shows that menorrhagia is the predominant presenting symptom in three different studies and in one study irregular bleeding was the main presenting bleeding abnormality.

Discussion

The endometrium has different appearance in different phases of the menstrual cycle. Essentially the endometrium consists of three structures: the endometrial lining epithelium, endometrial glands and stroma.

DUB denotes abnormality in normal cyclic menstrual flow, in amount, duration or interval caused by disturbances of endocrine mechanism that control menstruation. Most of the cases are due to anovulation, such cycles are common at both ends of reproductive life. Failure of ovulation may be due to dysfunction of HPO axis, adrenal or thyroid dysfunction, malnutrition, obesity or severe physical or emotional stress. It leads to estrogen excess. Thus endometrium goes through a proliferative phase that is not followed by normal secretory phase.

Table 6
Endometrial profile No of cases Percentage
Disordered Proliferative 85 35.42%
Proliferative 96 40.00%
Secretory 26 10.83%
Cystic atrophic 15 6.25%
Pill endometrium 9 3.75%
Simple hyperplasia without atypia 6 2.5%
Atypical hyperplasia 3 1.25%
Total 240 100%

Distribution of various endometrial profiles

Table 6 most common endometrial profile was proliferative pattern, seen in 40% of cases. This is followed by disordered proliferative endometrium, seen in 35.42% cases. Similar results of proliferative endometrium being the commonest were seen in Hoon CN et al,4 Muzaffar M et al,5 Maheshwari V et al,6 S. Kayastha7 and other studies.

In latter part of secretory phase, the glands become crenated and assume a corkscrew-shaped form later the glands become saw-toothed. Due to lack of progesterone support, endometrium collapses leading to bleeding. An excess of estrogen if prolonged will induce endometrial hyperplasia. DUB also develops when ovulation occurs but corpus luteum function is insufficient leading to irregular ripening of endometrium (luteal phase defect) or there may be abnormal persistence of corpus luteum leading to irregular shedding. Ovulatory DUB is associated with secretory endometrium. Hormonal imbalance is considered the root cause of hyperplasia of the endometrium that causes menorrhagia; this often happens in anovulatory cycles with excessive or unopposed influence of oestrogen on the endometrium.

Mild to moderate anemia was seen in many cases. A few cases had severe anemia requiring packed cell transfusion. Overall, the anovulatory bleeding was much more common than ovulatory bleeding in our study. The medical diseases which were found to be associated with DUB were diabetes mellitus, hypertension in the higher age group and anemia irrespective of age.

Hysteroscopy is the latest in the diagnostic armamentarium, specially useful when there is a endometrial polyp, where in polypectomy can also be done.

Conclusion

DUB is more commonly seen in perimenopausal age group. Prevalence is more in multipara. 49% presented with menorrhagia. There was no association between the various bleeding patterns and histopathology of endometrium.

Histopathological examination is a must to rule out local causes and help to determine mode of management. Unnecessary radical treatment can be avoided by performing histopathological study of endometrium got by uterine curettage.

Endometrial curettage followed by histopathological examination of the tissue is the definitive confirmatory test to rule out hyperplasia and malignancy. The thickness of endometrium measured by ultrasound is only indicative and not confirmatory.

Source of support

None declared

Conflict of interest

None declared

References

1 

Madhupatil R Shashikala Hiremath Bleeding patterns in DUB &correlation with histopathology of endometriumIndian J Obstetrics Gynaecol201861

2 

K B Seena V R Ajithkumar A study of dysfunctional uterine bleeding-clinical factors and endometrial histologyJ Evol Med Dent Sci20176191494149710.14260/Jemds/2017/327

3 

N Katuwal G Gurung A Rana A Jha Clinicopathological study of DUBJ Pathol Nepal20144635638

4 

C N Hoon P Chan C I Joon Clinicopathological study of the endometrium of dysfunctional uterine bleedingThe Korean J Pathol1989236574

5 

M Muzaffar K Akhtar S Yasmin M Rehman W Iqbal M Khan Menstrual irregularities with excessive blood loss: Aclinico pathological correlationJ Pak Med Assoc2005551630486816304868PMID

6 

A Maheshwari V Chakraborty S Tyagi R Sharma K Alam S Mohsin Endometrial changes in abnormal uterine bleedingJ Obstet Gynaecol1996334389394

7 

S Kayastha Nepal Med Coll J20131512730



jats-html.xsl